George Cremaschi was born in New York, where he studied music and composition. He later lived for many years in California and currently lives in Prague, where he teaches film sound at FAMU. 

Cremaschi makes use of a variety of approaches in the overlapping areas of music, sound art and noise. In thirty years as a composer and performer, he has a long and diverse history of working with musicians, filmmakers, dancers and choreographers, visual artists, and writers. Some of his current projects include the groups KRK (with Matthew Ostrowski), Rohr Rohr (with dieb13 and Gino Robair) and Lambs Gamble (with Fritz Welch and Eric Boros). Cremaschi is also a co-founder (with Petr Vrba) and director of Prague Improvisation Orchestra (PIO), a 15-member group that performs conducted free improvised, and graphic scores.

As an improviser he has worked with many people including Liz Allbee, Marshall Allen, Han Bennink, Greg Goodman, Mats Gustafsson, Joelle Leandre, Thomas Lehn, Paul Lovens, Louis Moholo, Butch Morris, Evan Parker, Rova Quartet, and Cecil Taylor.

As an interpreter, he has performed works by many composers including Adamčiak, Andriessen, Braxton, Cage, Cardew, Nicolas Collins, Feldman, Mingus, Oliveros, Penderecki, Tenney, Xenakis, among others, and has appeared on over 40 recordings on Apestaartje, Beak Doctor, Black Saint, Emanem, Evander, Evolving Ear, Leo, Music & Arts, Nine Winds, Rastascan and other labels.